The properties shared by neoplastic and embryonic cells have long been recognized and it has been postulated that both cell types may express a common set of molecules not found in adult tissues of the same histologic type. This study has utilized a rabbit antiserum raised against human fetal spleen to identify 'oncofetal' antigens of the human lymphoreticular system. One molecule found to have oncofetal properties was hemoglobin F (HbF). A radioimmunoassay was developed to measure the very low concentrations of HbF present in the adult circulation and an extensive clinical trial was undertaken to determine the possible value of detecting elevated HbF levels in various pathological conditions. In addition, 2 other antigenic systems, present on the surface of lymphoid cells, were identified. Some preliminary information on the nature and distribution of these antigens is presented
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.68498 |
| Date | January 1979 |
| Creators | James, Roger Frank Lever. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Medicine) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000090044, proquestno: AAINK50463, Theses scanned by UMI/ProQuest. |
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