Lipid is a major fuel in trauma and sepsis. Previous in vitro studies have demonstrated an increased $ beta sb1$-adrenergic stimulated lipolysis in the adipose tissue of trauma patients. With sepsis there was a decrease in $ beta sb1$ stimulated lipolysis. Subsequent in vitro studies have shown that E. coli endotoxin decreases $ beta sb1$-stimulated lipolysis and that this effect may be occurring at the level of the G-protein, a component of the $ beta$-adrenergic receptor mechanism. The object of this study is to demonstrate the effect of E. coli endotoxin on lipid metabolism in vivo and to correlate this with in vitro receptor data obtained using adipose tissue biopsies.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.59855 |
| Date | January 1990 |
| Creators | Meterissian, Sarkis |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001167743, proquestno: AAIMM66488, Theses scanned by UMI/ProQuest. |
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