The family history and comorbidity of 97 sequential outpatients with DSM-III panic disorder (with or without agoraphobia) was examined. Patients were diagnosed by a psychiatrist and 71 were additionally diagnosed via structured clinical interview (SCID or A-DIS-R). All subjects resided in the province of Quebec. Subjects consisted of two groups: patients referred for treatment and patients recruited by a newspaper advertisement for a drug study on panic disorder. The age of onset in both groups was inversely related to having a family history of panic disorder, or anxiety disorders, or major affective disorders, or substance abuse disorders. To evaluate the presence of psychopathology in family members a semi-structured family history interview was used throughout. Multigenerational panic disorder was defined as having three or more affected relatives in at least two generations. This familial form of panic disorder was present in 15% of the pedigrees overall. There was a significant difference between the two groups in regard to family history of major affective disorder with the referral group having significantly more probands with a family history of major affective disorder. There was no difference between groups with respect to panic disorder, anxiety disorders, or substance abuse disorders. Age of onset of panic disorder was significantly lower in probands who were referred for treatment than those recruited for the drug study. / Subjects were then recombined with respect to a history of comorbid depression. The presence of a comorbid diagnosis of depression in the proband predicted a multigenerational family history of major affective disorder.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.55506 |
| Date | January 1994 |
| Creators | Lane, Carol Mayne Jacqueline |
| Contributors | Palmour, R. M. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Psychiatry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001426092, proquestno: AAIMM00033, Theses scanned by UMI/ProQuest. |
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