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Design and Synthesis of Thiamine Analogs as Anti-Cancer Therapeutics

Cancer is one of the leading causes of death. There have been many investigations into therapeutic ways to prevent and reverse cancerous growth. We report a new approach in this thesis, which is to investigate the functions of Vitamin B1 (thiamine) in cancerous cells and their regulation. A number of thiamine analogs were synthesized to carry out the structure-activity relationship (SAR) studies with two transporters THTR1 and THTR2. Initial results show that the modifications of thiazole reduced the uptake of thiamine.

Identiferoai:union.ndltd.org:GEORGIA/oai:digitalarchive.gsu.edu:chemistry_theses-1051
Date11 August 2012
CreatorsDinh, Hieu T.
PublisherDigital Archive @ GSU
Source SetsGeorgia State University
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceChemistry Theses

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