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Optical Brain Imaging of Motor Cortex to Decode Movement Direction using Cross-Correlation Analysis

The goal of this study is to determine the intentional movement direction based on the neural signals recorded from the motor cortex using optical brain imaging techniques. Towards this goal, we developed a cross-correlation analysis technique to determine the movement direction from the hemodynamic signals recorded from the motor cortex. Healthy human subjects were asked to perform a two-dimensional hand movement in two orthogonal directions while the hemodynamic signals were recorded from the motor cortex simultaneously with the movements. The movement directions were correlated with the hemodynamic signals to establish the cross-correlation patterns of firings among these neurons. Based on the specific cross-correlation patterns with respect to the different movement directions, we can distinguish the different intentional movement directions between front-back and right-left movements. This is based on the hypothesis that different movement directions can be determined by different cooperative firings among various groups of neurons. By identifying the different correlation patterns of brain activities with each group of neurons for each movement, we can decode the specific movement direction based on the hemodynamic signals. By developing such a computational method to decode movement direction, it can be used to control the direction of a wheelchair for paralyzed patients based on the changes in hemodynamic signals recorded using non-invasive optical imaging techniques.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc1609111
Date12 1900
CreatorsLebel, Cynthia
ContributorsTam, Nicoladie D., Burleson, Mark L., Vaidyanathan, Vijay
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatvi, 51 pages, Text
RightsPublic, Lebel, Cynthia, Copyright, Copyright is held by the author, unless otherwise noted. All rights Reserved.

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