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Chemical Constituents of the Formosan Soft Coral Nephthea chabrolii

Numerous bioactive secondary metabolites including sesquiterpenoids,diterpenoids, meroditerpenoids, and steroids have been isolated from the soft corals of the genus Nephthea. In order to search for novel bioactive substances from marine organisms, we have investigated the secondary metabolites of the organic extract of the soft coral Nephthea chabrolii collected at San-Hsian-Tai. Chromatographic fractionation of the acetone-soluble has led to the isolation of four 19-oxygenated steroids 1¡V4 and two 19-norergosterols 5, 6, along with twelve known compounds 7¡V18.
The structures of these compounds were determined on the basis of their spectroscopic analysis data (1H NMR, 13C NMR, 1H¡V1H COSY, HSQC, HMBC, NOESY, IR, and HRESIMS), physical data and compared with the literature data. The cytotoxicity against of A-549 (human lung epithelial carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cells, and anti-HCMV (human cytomegalovirus) activity of compounds 1¡V6 were evaluated. Metabolites 1¡V6 displayed cytotoxicity against P-388 cell line with ED50 values of 0.93, 1.05, 1.20, 1.74, 1.19, 1.19 £gg/mL. However, none of them exhibited inhibitory activity against HCMV (human cytomegalovirus).

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0910112-122821
Date10 September 2012
CreatorsPuu, Shyh-Yueh
ContributorsChang-Yih Duh, Jyh-Horng Sheu, Ian-Lih Tsai, Fang-Rong Chang, Chih-Chuang Liaw
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageCholon
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0910112-122821
Rightsuser_define, Copyright information available at source archive

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