Strain differences have previously been observed in the anxiolytic effect of the Angiotensin Type I receptor (AT1 R) antagonist losartan in mice. Structural variation in key binding sites, AT1 receptor binding, AT1 expression, the effect of a microsatellite in the promoter region of the gene and the influence of angiotensin receptor associated protein (ATRAP) were investigated for association with this observed behavioural variation.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:518245 |
| Date | January 2009 |
| Creators | Golding, Bruno J. D. |
| Publisher | University of Brighton |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | https://research.brighton.ac.uk/en/studentTheses/72990e34-ef32-490c-a724-4ef9a66f67f9 |
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