Recurrent pregnancy loss is associated with anti-phospholipid antibodies (aPL), in particular in women with anti-phospholipid syndrome. aPL are a large family of autoantibodies, directed against phospholipids and phospholipid-binding proteins (e.g., prothrombin and beta2-glycoprotein I). Although the association between aPL and recurrent pregnancy loss is well documented, little is known about which aPL subset is responsible. To address this, we characterized a panel of six murine monoclonal aPL, which were subsequently administered to pregnant mice via passive transfer. While both anti-beta2GPI antibodies evaluated caused significant increase in fetal resorption, the effects of anti-PT antibodies varied from no effect to increased pregnancy loss. Similarly, neither lupus anticoagulant activity nor murine cross-reactivity predetermined aPL pathogenicity. We conclude that there is no obvious common reactivity between the aPL capable of increasing pregnancy loss, suggesting that a combination of reactivities, rather than one aPL specificity in particular, may lead to aPL-mediated pregnancy loss.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.82414 |
| Date | January 2004 |
| Creators | Robinson, Cheryl |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Experimental Medicine.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002201557, proquestno: AAIMR12529, Theses scanned by UMI/ProQuest. |
Page generated in 0.0011 seconds