Studies of proteoglycan-induced arthritis in mice revealed two previously unidentified features: polymorphonuclear leucocytes in knee joint cavities and sacroiliac joint involvement. Immunological studies of cellular responses to the proteoglycan revealed a lack of response prior to arthritis which was produced by a further injection. Further studies revealed that depletion of suppressor/cytotoxic T cells in vitro led to an increased response to antigen. Cellular responses in immune and preimmune mice involve helper T lymphocytes. The preimmune but not immune responses wee inhibited by mouse serum and involved a helper T cell dependent response. It did not involve detectable cell death or suppressor/cytotoxic T lymphocytes. Bacteria isolated from mice did not produce arthritis and showed no immune cross-reactivity with proteoglycan.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.61247 |
| Date | January 1989 |
| Creators | Mathai, Lalitha |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Microbiology and Immunology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000911124, proquestno: AAIMM75854, Theses scanned by UMI/ProQuest. |
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