The cellular basis for genetically-determined differences in resistance to infection with Listeria monocytogenes has been investigated in Listeria-resistant and Listeria-sensitive mouse strains. Adoptive transfer of specific immunity to naive recipients of sensitive and resistant genotypes has shown that the gene (Lr) controlling the level of resistance is expressed in the macrophage, rather than in the T-cell, response. In resistant mice, shortening of promonocyte generation time (T(,G)), together with prompt monocytosis and decreased half-time (T(, 1/2)) of circulating monocytes is seen following infection or injection of listerial cell wall extract; furthermore, the enhanced antilisterial response of resistant mice is highly radiosensitive indicating participation of an immigrant, inflammatory macrophage. Studies in chimeras constructed between sensitive and resistant strains have shown that high resistance is a property of the host environment in which the macrophage precursors mature. Thus, high antilisterial resistance is attributed to an Lr gene product which promotes early arrival of large numbers of young mononuclear phagocytes at infective foci, which destroy the pathogen.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.68619 |
| Date | January 1981 |
| Creators | Punjabi, Chitra J. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Physiology) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000137643, proquestno: AAINK54890, Theses scanned by UMI/ProQuest. |
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