Previous studies have established that sensitivity (IgE antibody response) to Ra5S, a 5 kd protein of short ragweed pollen, is significantly associated with host possession of HLA-Dw2/DR2 (Bias et al., 1979; March et al., 1982a; Coulter, 1983). The present work was undertaken to determine a possible association between HLA and sensitivity to Ra5G, an Ra5S homologue from giant ragweed pollen. The DR2 allele was also implicated in sensitivity to Ra5G, on the basis of co-sensitivity to both proteins (Goodfriend et al., 1985). Further analysis with an enlarged RW allergic population demonstrated that sensitivity to Ra5G and Ra5S is associated with separate alleles: DRw52 and DR2 respectively. Results consistent with the same sensitivity/DR associations were obtained in immunoabsorption studies with sera from co-sensitive individuals. As HLA-DR2 and DRw52 have identical alpha but different beta chains, it was considered that IgE antibody responses to Ra5S and Ra5G are associated with distinct DR-beta genes.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.75370 |
| Date | January 1987 |
| Creators | Coulter-Hennekens, Kelsye |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Microbiology and Immunology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000419905, proquestno: AAINL38349, Theses scanned by UMI/ProQuest. |
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