Although much information has accumulated in recent years on the cellular origin and mechanism of antibody synthesis, very little is known about the way in which antigens exert their effect on the induction of antibody formation. A number of investigators (1, 2, 3, 4, 5, 6) feel that antigens probably must be split into fragments to initiate antibody production and that these subunits may correspond in size to the dimensions of the antibody-combining sites (3). Antibodies reacting with antigenic fragments prepared in vitro have been found in rabbit antisera against human and bovine serum albumin (4, 7, 8, 9) and some of these antibodies appeared to be directed against antigenic groups not present on the surface of the native protein (9).
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.115144 |
| Date | January 1963 |
| Creators | Larose, Claude. L. |
| Contributors | Rose, B. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science. (Department of Experimental Medicine) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: NNNNNNNNN, Theses scanned by McGill Library. |
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