Endogenous cholesterol (Ch) fractional synthesis rate (FSR) is inversely related to infant dietary Ch at 4 months (mo) of age. The objective of the present study was to determine whether level of infant dietary Ch induced changes in FSR that persisted at 18 mo. Forty-seven infants received, human milk (HM) from birth until weaned (n=15), or were randomized to receive modified cow-milk formula (MCF) with added Ch (n=15), or cow-milk formula (CF, n=17), for 12 mo. Ch contents of HM, MCF, and CF were 120, 80, and 40 mg/L, respectively. At 4 mo, FSR in the HM group was lower than in CF, but at 18 mo, there were no differences between groups. Therefore, while Ch intake prior to weaning affects FSR, the differences do not persist after weaning to unrestricted diet. These data provide further evidence that there is no imprinting of FSR in infancy by differing dietary levels of Ch. / Le taux de synthèse fractionée (TSF) du cholestérol (Ch) endogène est inversement proportionnel à la prise alimentaire du Ch à 4 mois (mo). L’objectif de cette étude était de verifier si ces différences du TSF persistent à 18 mo. Quarante-sept enfants ont reçu, dès la naissance, soit lait maternel (HM), jusqu’au sevrage (n=15), ou ont reçu de façon aléatoire soit du lait maternisé (CF), à base lait de vache (n=17), ou une formule modifiée par l’addition de Ch (MCF, n=15) durant 12 mo. Les HM, CF, et MCF contenaient respectivement 120, 80, 40 mg/L de Ch. À 4 mois, le TSF dans HM était plus faible que chez CF, mais cette différence avait disparue à 18 mois avec le sevrage au régime sans restriction. Ces données confirment que le Ch alimentaire chez le nourrisson n’affecte pas le TSF de façon permanente. fr
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.18193 |
| Date | January 2004 |
| Creators | Demmers, Thea |
| Contributors | Peter J. H. Jones (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | French |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Dietetics and Human Nutrition) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | Electronically-submitted theses. |
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