The effect of simultaneous ingestion of L-amino acids and whole protein on plasma amino acid concentrations was investigated in 10 males, ages 18.5 to 33.9 years. Subjects ingested in trial one, low fat cottage cheese, in trial two an L-amino acid mixture simulating the composition of cottage cheese and in trial three a combination of cottage cheese and the L-amino acid mixture. Each trial provided one-third of the subjects' daily protein requirement and equivalent amounts of amino acids. Blood samples for plasma amino acid analyses were obtained from subjects before each trial and at 30, 60, 90, 120, 150, 180 and 240 minutes postprandially. Mean changes in total plasma amino acid concentrations between trials one and two and trials one and three at 30 minutes (p $\leq$ 0.05) and between trials one and three at 150 minutes (p $\leq$ 0.10) differed significantly. Mean changes in essential plasma amino acid concentrations between trials one and two and trials one and three at 30 minutes (p $\leq$ 0.05) and between trials one and three at 60 and at 150 minutes (p $\leq$ 0.10) differed significantly. The results of this study show that under physiological conditions mean increments in total, essential and individual plasma amino acid concentrations were higher, peaked faster, but decreased more quickly after ingestion of L-amino acids alone or with whole protein than after ingestion of whole protein alone. Ingestion of either L-amino acids, whole protein or the mixture of L-amino acids and whole protein was equally effective in increasing total plasma amino acids concentrations over the four hour time period. Further studies assessing the effects of different sources of nitrogen on nitrogen balance and on protein synthesis are required in individuals with normal gastrointestinal function to establish when L-amino acid mixtures should be administered in relation to whole protein ingestion. / Source: Dissertation Abstracts International, Volume: 48-12, Section: B, page: 3533. / Thesis (Ph.D.)--The Florida State University, 1987.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_76200 |
| Contributors | GROPPER, SAREEN ANNORA STEPNICK., Florida State University |
| Source Sets | Florida State University |
| Detected Language | English |
| Type | Text |
| Format | 149 p. |
| Rights | On campus use only. |
| Relation | Dissertation Abstracts International |
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