In humans, the overall birth frequency of trisomy 21 (Downs syndrome) is 1 per 700 livebirths. The incidence at conception is greater, but more than 80% will not reach term (Connor and Ferguson-Smith 1985). Presumably, numerous factors, genetic and environmental are influencing this process. Therefore, an analysis of the factors modulating the survival of murine aneuploid embryos has been initiated. / A maternal genetic control modulating the survival of murine trisomic embryos has been observed at day 15 of gestation (Vekemans and Trasler 1987; Epstein and Vekemans 1990). To determine whether this modulation is taking place, before or after implantation, the analysis of aneuploid blastocysts has been started. / The frequency of aneuploidy observed at the blastocyst stage has been found not to differ when the maternal genotype varied for both murine chromosomes 19 and 16. Therefore, we can conclude that the maternal genetic control modulating the survival of trisomic embryos at day 15 of gestation is not in effect at the preimplantation stage. / Also we observed that genetic factors are modifying the blastocyst development (e.i. the cavitation process).
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.60419 |
| Date | January 1990 |
| Creators | Jacob, Christine |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001167896, proquestno: AAIMM66465, Theses scanned by UMI/ProQuest. |
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