This investigation examines cell proliferation in the pancreas of the Syrian golden hamster. Three main themes are pursued. First, normal pancreatic growth and development is reviewed. Emphasis is placed on histogenesis and trophic stimuli. Secondly, modulation of pancreatic growth is examined. A new method for producing partial pancreatic duct obstruction using a technique of cellophane wrapping is described. The histologic alterations induced by wrapping are the same as those associated with the early changes of chemical pancreatic carcinogenesis--duct epithelial hyperplasia, metaplasia and nesidioblastosis. Morphometric, immunocytochemical, autoradiographic and G.I. hormone analysis are also utilized to characterize this model. Importantly, experimental nesidioblastosis can result in islets which are functionally capable of reversing streptozocin-induced diabetes. Thirdly, aberrant pancreatic growth was investigated in relation to carcinogenesis. Clinical cancer epidemiology is reviewed with special reference to risk factors and postulated trophic influences. Experimentally, the trophic effects of diet, cholecystectomy and duct obstruction were investigated. Finally a new model for the induction of carcinoma of the head of the pancreas, using cellophane wrapping in association with a chemical carcinogen, is presented.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.71948 |
| Date | January 1984 |
| Creators | Rosenberg, Lawrence. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000214514, proquestno: AAINL20806, Theses scanned by UMI/ProQuest. |
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