Estrogen and progesterone receptors were localized in fresh frozen sections of human endometrial tissues, in both health and disease, using the ER-ICA kit and a mouse monoclonal antiprogesterone receptor antibody ($ alpha$PR6), respectively. Estrogen and progesterone receptors were detected exclusively in the nuclei of epithelial and stromal cells of the endometrium. Their highest levels in both components were found during the late proliferative phase of the normal menstrual cycle. Estrogen receptors decreased faster in the stroma than in the epithelium throughout the post ovulatory phase, whereas progesterone receptors decreased more rapidly in the epithelium during the mid and late secretory phases. Estrogen and progesterone receptor levels were high in the epithelium of hyperplasia without cytologic atypia. They were low in the epithelium of endometrial intraepithelial neoplasia (hyperplasia with cytologic atypia) and the majority of invasive carcinomas. The stroma contained relatively high estrogen and progesterone receptors levels, irrespective of whether the epithelium was hyperplastic or neoplastic.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.75995 |
| Date | January 1989 |
| Creators | Bergeron, Christine |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000936597, proquestno: AAINL57350, Theses scanned by UMI/ProQuest. |
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