By techniques of immunohistochemical staining, flow cytometry, and image analysis, the present study demonstrated the following: (1) The ST3 antigen is expressed on the surface of thymocytes of young rats, and decreases in both percentage and intensity with increasing age (after 12 months). (2) The ST3 antigen also is expressed on the surface of thymic nurse cells. Although the majority of lymphoid cells within nurse cells also bear the ST3 antigen, a subpopulation contains lymphocytes that do not. These results suggest that the ST3 antigen may be a useful new marker for cortical lymphocytes, and imply that its expression may play a role in intra-thymic T-cell development, and in senescence of the organ.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.26172 |
| Date | January 1993 |
| Creators | Wang, Jian Xue |
| Contributors | Sullivan, A. (advisor), Michel, R. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001397695, proquestno: MM94539, Theses scanned by UMI/ProQuest. |
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