Background. Peripheral vein infusion thrombophlebitis (PVIT) is a complication of intravenous therapy. We hypothesized that inherited thrombophilia may increase the risk of PVIT. / Purpose. In preparation for a multi-center study of our hypothesis, we conducted a pilot study to estimate PVIT incidence, measure the prevalence of inherited thrombophilia, and pilot test the study procedures. / Methods. A prospective case-control study of 25 cases (patients with PVIT) matched on catheter duration to 25 controls. PVIT risk factors and inherited thrombophilia were assessed. / Results. PVIT incidence was 14 per 1000 catheter-days. There were no significant differences in the prevalence of the inherited thrombophilia disorders among cases and controls (32% vs. 48%). A previous history of PVIT was noted in 4 cases compared to 0 controls. Procedural problems included a high rate of non-consent and inadequate communication with the laboratory. / Conclusions. Though an association between PVIT and inherited thrombophilia was not shown, a previous history of PVIT among cases supports a biological predisposition to PVIT. Our pilot study did provide useful data on PVIT incidence and procedural issues used to design a more definitive study of inherited thrombophilia and PVIT.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.79140 |
| Date | January 2002 |
| Creators | Tagalakis, Vasiliki |
| Contributors | Kahn, Susan (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001974970, proquestno: AAIMQ88310, Theses scanned by UMI/ProQuest. |
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