Obliterative bronchiolitis (OB) is the leading cause of chronic irreversible lung graft failure. It is assumed by many to be caused by chronic rejection. We hypothesized that non-specific airway inflammation induced by factors such as foreign airway deposited particles, antigens and microbes is essential for the development of OB after lung transplantation (LTx). In this study, we examined the histological and immunohistological changes in allografted airways following transtracheal installation of foreign irritant particles. / Inadequate immunosuppression of lung allografts leads to severe vascular changes consistent with chronic vascular rejection but fails to induce airway inflammation and OB. The addition of a nonspecific foreign irritant was necessary to induce diffuse airway inflammation and OB in our animal model. This suggests that a co-factor inducing airway inflammation, such as deposited foreign particles or infections, is likely necessary for the development of OB after lung transplantation. Cytokine expression reveals a link between the observed influx of airway inflammatory cells and IL-8. While bFGF is associated more with the proliferative phases of airway and vascular injury. These markers however are not predictive of either rejection or OB, due to the expression of both these markers in all three study groups. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.23909 |
| Date | January 1996 |
| Creators | Lee, Allan G. L. |
| Contributors | Shennib, Hani (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001495005, proquestno: MM12223, Theses scanned by UMI/ProQuest. |
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