The effect of disturbed flows on mass transfer to and from an arterial wall was studied both theoretically and experimentally using an idealized model of arterial stenoses in which an annular ring vortex was formed. It was found that the transport of macromolecules, including low density lipoproteins, from flowing blood to a semi-permeable vessel wall is greatly enhanced in regions of disturbed flow with a local maximum locating around the reattachment (stagnation) point. The surface concentration of macromolecules increases with increasing the filtration velocity and decreasing the flow rate. The disturbed flows also facilitated the transport of low molecular weight substances such as biochemicals but not macromolecules from arterial walls to flowing blood. These results strongly suggest that disturbed flows with slow recirculation flow provide favorable conditions for the genesis and development of atherosclerotic lesions by affecting local mass transport phenomena at the blood-vessel wall boundary.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.70234 |
| Date | January 1991 |
| Creators | Deng, Xiaoyan |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Chemical Engineering.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001257422, proquestno: AAINN72166, Theses scanned by UMI/ProQuest. |
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