Schneiderian papillomas (SP) are tumors arising from the surface epithelium (Schneiderian epithelium) of the nasal cavity and paranasal sinuses. Evidence points towards a viral etiology, specifically Human papillomavirus (HPV). Although substantial data indicates HPV as a likely etiology, little is known about the role of HPV in benign nasal pathologies or in normal nasal mucosa. Objective. To characterize the role of HPV in SP, chronic sinusitis (CS) and its prevalence in normal nasal mucosa. A case controlled study was undertaken, matching patients with SP to patients with chronic sinusitis (CS). Patients with normal nasal mucosa served as a control group. All patients had their tissues analyzed for the presence of various HPV types using polymerase chain reaction (PCR) coupled with a line blot assay. Results. A total of 168 patients were identified (74 SP, 74 CS, 20 control). Of these, 70 (41.7%) had detectable DNA, and 9/70 (12.9%) had detectable HPV of types 6, 11, and 16. None had detectable HPV type 18. Significant differences were detected in the presence of HPV in CS, SP and control groups, as well as in the presence of low risk versus high-risk types amongst investigation and control groups. Conclusions. Significant differences exist in the distribution of HPV between SP, benign nasal pathologies such as CS and normal nasal mucosa. HPV may play an important role, at least as cofactor, in the development of SP, with types 6, 11 and 16 more pivotal than other types. Line blot assay may provide a useful technique in identifying HPV in SP.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.31561 |
| Date | January 2001 |
| Creators | Yoskovitch, Adi. |
| Contributors | Frenkiel, Saul (advisor), Franco, Eduardo (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Otolaryngology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001803223, proquestno: MQ70531, Theses scanned by UMI/ProQuest. |
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