Post-poliomyelitis syndrome (PPS) is a clinical syndrome of new weakness, fatigue, and pain in individuals who have previously recovered from acute paralytic poliomyelitis. The primary objective of this study was to identify factors which predict subsequent PPS. Among patients with prior polio, cases were those with new weakness and fatigue, and controls were those without these complaints. A chart review of 353 patients evaluated at the Montreal Neurological Institute post-polio clinic identified 127 cases and 39 controls. In univariate analyses, significant risk factors for PPS were a greater current age (odds ratio of 1.8 per decade, 95% confidence interval 1.3 to 2.6), a longer time since acute polio (odds ratio of 1.6 per decade, 95% confidence interval 1.1 to 2.3), more weakness at acute polio (odds ratio 1.5, 95% confidence interval 1.1 to 2.0), a recent weight gain (odds ratio 3.8, 95% confidence interval 1.6 to 9.4), muscle pain with exercise (odds ratio 3.8, 95% confidence interval 1.5 to 9.5), muscle pain (odds ratio 2.6, 95% confidence interval 1.3 to 5.5), and joint pain (odds ratio 2.3, 95% confidence interval 1.1 to 5.3). The multivariate analyses revealed that a model containing current age (odds ratio 1.7 per decade, 95% confidence interval 1.1 to 2.6), weakness at acute polio (odds ratio 1.6, 95% confidence interval 1.1 to 2.5), muscle pain with exercise (odds ratio 4.9, 95% confidence interval 1.6 to 15.6), recent weight gain (odds ratio 6.4, 95% confidence interval 2.02 to 20.3), and joint pain (odds ratio 2.33, 95% confidence interval 0.8 to 7.1) was the most effective in predicting who would develop PPS. Age at acute polio, degree of recovery after polio, weakness at best point after polio, physical activity, and sex were not contributing factors.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.56985 |
| Date | January 1992 |
| Creators | Trojan, Daria A. (Daria Anna) |
| Contributors | Esdaile, John M. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001320179, proquestno: AAIMM87726, Theses scanned by UMI/ProQuest. |
Page generated in 0.0017 seconds