A growing line of evidence indicates that the proper control of DNA methyltransferases (DNMT) and DNA demethylases is critical for maintaining correct gene expression. In addition, misregulation of this machinery likely plays a role in the aberrant DNA methylation patterns and gene expression that is a hallmark of many pathologies such as cancer. A greater comprehension of the mechanisms involved in regulating the expression and activity of these proteins should provide new therapies aimed at restoring gene expression gone wrong.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.19406 |
| Date | January 2003 |
| Creators | Detich, Nancy |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Pharmacology & Therapeutics) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002009000, Theses scanned by McGill Library. |
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