The present investigation validated a time-sampling method of scoring formalin-induced pain-specific behaviours. The method improves efficiency by at least a factor of five, and also provides measures of other aspects of behaviour, without the loss of statistical power of the results. Formalin-induced behaviours were examined over the entire range of commonly used formalin concentrations, for a prolonged period of time. The pain response increased dose-dependently up to 2% formalin in the first phase and up to 10% in the second phase if behaviour was scored for at least 90 minutes postformalin. Significant residual pain occurred only at 10% formalin. When morphine dose-effect relationships were examined at varying formalin concentrations, there was a systematic rightward shift in the morphine dose-effect relationships up to about 2% formalin, at which point, further increases in formalin concentration did not produce any further shift, and morphine appeared to noncompetitively antagonize formal in-induced pain. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29916 |
| Date | January 1999 |
| Creators | Ocvirk, Rok. |
| Contributors | Abbott, Frances V. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Psychiatry.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001681446, proquestno: MQ55083, Theses scanned by UMI/ProQuest. |
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