The Brazilian Wilms' Tumor Study Group carried out a case-control study of Wilms' tumour (WT) to identify risk factors for the development of WT. Two controls per case, matched for sex, age (${ pm12}$ months), hospital and interviewer, were chosen. Controls were children admitted to hospital for conditions other than neoplasms. Pediatricians interviewed parents of 109 cases and 218 controls. / Increasing levels of parental education and family income were associated with the diagnosis of WT, probably the result of selecting a hospitalized control group. The positive association between high family income and WT was strongest among the cases diagnosed early, and absent among the cases diagnosed late. / Parental occupational exposure to pesticides or herbicides before the pregnancies of the subjects was identified as a risk factor, with a significant trend for increasing risk with increasing cumulative frequency of use. / Also identified as risk factors were maternal consumption during the pregnancy of coffee in excess of 2 cups/day and of dipyrone, an analgesic (both among the lowest income group), and of alcoholic beverages (among the most educated).
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.26136 |
| Date | January 1993 |
| Creators | Sharpe, Colin R. |
| Contributors | Franco, Eduardo L. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001397201, proquestno: MM94520, Theses scanned by UMI/ProQuest. |
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