The brain can be explored while a subject executes different tasks. Such techniques are commonly referred as activation studies. The regions of the brain involved in a particular task can be located by comparing regional differences in tracer concentration to a control state. Group of neurons in the brain form complex logical circuits and their activities increase while they interpret a stimulation. These neuronal activities require glucose and oxygen and these substances travel in the blood following hemodynamic rules. Many factors influence the hemodynamic response induced by brain activation (FRIBA), but certain aspects of its temporal behavior are still unclear. A special technique was implemented with an ECAT EXACT HR+ (CTI/Siemens) to fulfil this lack in PET activation studies. The new HR+ has this 3D option, which can help to evaluate the FRIBA with a tracer (11C-CO) that remains in the blood vessels to measure the cerebral blood volume (CBV) differences. Only CBV studies can appreciate the temporal course of the FRIBA in PET. The resulting images are, however, very noisy and many pitfalls are present during their analysis. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.30758 |
| Date | January 2000 |
| Creators | Tremblay, Hugo. |
| Contributors | Thompson, Christopher J. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | French |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001740522, proquestno: MQ64469, Theses scanned by UMI/ProQuest. |
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