Bone marrow transplantations frequently result in a graft-versus-host reaction (GVHR) even when donors and recipients are HLA matched. / In the present work with mice, an experimental protocol was designed to verify whether or not a GVHR ensuing immunosuppression can occur even in the absence of a difference at the level of the major histocompatibility antigens. / Injection of lymphoid cells from donors histoincompatible with recipients at the level of one or multiple minor antigens induced a GVHR resulting in a marked decrease of humoral response of the recipients, and also a lack of ability of their lymphocytes to respond to mitogens. / This immunosuppression was associated with the presence of suppressor cells in the spleen of these animals. Furthermore histopathological studies demonstrated that the thymuses from animals experiencing a late GVHR induced across multiple minor histocompatibility antigens, showed signs of dysplasia.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.72039 |
| Date | January 1985 |
| Creators | Brousseau, Pauline. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | French |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Division of Experimental Medicine.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000222601, proquestno: AAINL24038, Theses scanned by UMI/ProQuest. |
Page generated in 0.0018 seconds