The murine F$ sb1$ hybrid model of graft-versus-host (GVH) disease was used to investigate the nature of GVH-induced T cell immunodeficiency. Chronic GVH reactions were induced in BAF$ sb1$ mice by the i.v. injection of 50 $ times$ 10$ sp6$ parental A strain lymphoid cells. At various days (43-139) after GVH induction the thymi and spleens were excised and used for in vitro functional studies. In addition, both lymphoid and non-lymphoid organs were evaluated histologically. Interleukin 1 (IL-1) and 2 (IL-2) were used as probes to assess the functional status of the peanut agglutinin positive (PNA$ sp-$) and peanut agglutinin negative (PNA$ sp+$) subpopulations. The results obtained strongly suggest that GVH-induced T cell immunodeficiency is due in part to a decreased responsiveness to IL-1 and IL-2, and to a marked deficiency in IL-2 production.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.75444 |
| Date | January 1987 |
| Creators | Mendes, Mariza L. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Physiology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000547758, proquestno: AAINL44383, Theses scanned by UMI/ProQuest. |
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