Background. Several epidemiological studies have established an association between chlamydia pneumoniae (CP) and coronary artery disease. The aim of this study was to test the hypothesis that seropositivity to CP, cytomegalovirus (CMV), or Epstein-Barr virus (EBV) is associated with decreased endothelial function in healthy young men. / Methodology. A convenience sample of 65 male volunteers, ages 20 to 45, with no known coronary atherosclerosis or risk factors for coronary artery disease were enrolled in a seroepidemiological cross-sectional study. / Conclusion. A lack of association between chronic infection to CP, CMV, and EBV with endothelial function was observed. This finding suggests that these infectious agents are not implicated as etiological triggers in the genesis of coronary artery disease but does not preclude active involvement at later stages of the pathophysiological process, such as acceleration of atherosclerosis and acute plaque rupture. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29445 |
| Date | January 2002 |
| Creators | Khairy, Paul |
| Contributors | Shapiro, Stan (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001944879, proquestno: MQ85797, Theses scanned by UMI/ProQuest. |
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