Osteoarthritis (OA) is a degenerative, age related disease of diarthrodial joints. In OA, there is increased cleavage of type II collagen by collagenases in articular cartilage. This excessive cleavage can be caused by the altered feedback regulation of gene expression in chondrocytes by collagen type II or its degradation products which may serve as regulators of collagenase synthesis and activity through a cell surface receptor-mediated mechanism. The aim of the present study was to investigate the expression and production of collagen receptors, DDR-1 and DDR-2 in human adult normal and OA articular chondrocytes and to determine whether this correlates with the expression of disease related genes such as type X collagen, a specific marker for chondrocyte hypertrophy. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.29469 |
| Date | January 2002 |
| Creators | Rahnema, Nazanine |
| Contributors | Poole, A. Robin (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001940891, proquestno: MQ85819, Theses scanned by UMI/ProQuest. |
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