Melanoma-associated antigen (MAA) MART-1/Melan-A has been described in human cutaneous melanoma. The first objective of this study was to investigate the expressivity of MART-1/Melan-A in primary uveal melanomas. 56 formalin-fixed, paraffin-embedded human uveal melanomas were analyzed by immunohistochemistry. MART-1/Melan-A was found to be positive in 73% of cases, with almost 50% of tumours showing a diffuse involvement. The second objective was to investigate the expression of MAA Mart-1/Melan-A and gp100 in primary and metastatic human uveal melanoma lesions developed in albino rabbits. MART-1/Melan-A and gp100 were expressed in all primary lesions, with mainly focal distribution. Conversely, MART-1/Melan-A and gp100 exhibited a homogeneous pattern in the metastatic lesions, which implies upregulation of these antigens during disease progression. It may be postulated that MART-1/Melan-A and gp100 would be effective immunomarkers for immunotherapeutic strategies in human uveal melanoma.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.21622 |
| Date | January 1999 |
| Creators | Peschlow, Alexandra. |
| Contributors | Burnier, M. N., Jr. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001652892, proquestno: MQ50855, Theses scanned by UMI/ProQuest. |
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