Initiating a computerized population-based registry of Alzheimer's disease (AD), the IMAGE Project has developed a multimatrix model to investigate the disease. Part of the IMAGE Project 1, the neuropathological study, is designed to correlate clinical, neuropsychological and neuropathological features of AD for characterization of subtypes. This thesis reports mainly the morphometrical studies associated with project 1. / The study, based on (a) brain autopsy, (b) standardized histopathology, and (c) quantitative morphometry, shows heterogeneity in pathophenotypes of AD. Four morphological subgroups have been presently recognizes, by their characteristic histological abnormalities, and the densities, the distribution, and progression patterns of their lesions. The heterogeneity in pathophenotypes indicates that AD is not a disease with a single cause, but rather a syndrome with multiple elements involved in etiology and pathogenesis. These lead to different pathological features, and correspondingly, similar, but distinguishable clinical expressions.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.61223 |
| Date | January 1992 |
| Creators | Xu, Chun |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Pathology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001276950, proquestno: AAIMM74924, Theses scanned by UMI/ProQuest. |
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