In this thesis, physical and biological aspects of three linear-accelerator-based stereotactic radiosurgery techniques, namely the dynamic rotation, static conformal beam, and intensity-modulated beam, are compared. Comparisons are carried out using simulated targets which include spheres, hemispheres and a C-shaped target wrapped around a critical structure, inserted within modified slabs of an Alderson Rando anthropomorphic phantom. The phantom is CT-scanned with a stereotactic frame, and the images are transferred to the treatment planning systems. The best possible treatment plans are generated for each simulated target and for each of the three techniques. Treatment plans are compared using both physical (homogeneity and conformity indices) and biological parameters (integral biologically effective dose, tumour control probability and normal tissue complication probability). Possible correlation between physical and biological parameters is investigated for the three techniques. Finally, some experiments are performed to explain the lack of correlation obtained when multiple isocenters are employed in the dynamic rotation technique for the treatment of irregular targets.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.19455 |
| Date | January 2003 |
| Creators | Oliveira, Silvana C. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002010479, Theses scanned by McGill Library. |
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