The technique of functional magnetic resonance imaging (fMRI) is rapidly developing from one of technical interest to wide clinical application. fMRI exploits the fact that brain neural activity produces a change in blood oxygenation level dependent (BOLD) response which is recorded at each point in the brain. In a typical experiment, a subject is given a stimulus or cognitive task, and the statistical question is to relate it to the BOLD response, usually via a linear model. The BOLD response is not instantaneous; it is delayed and smoothed by about 6 seconds. In this thesis we propose a rapid method of estimating and making inference about this delay. Our method is compared to other alternatives, and validated on an fMRI data set from an experiment in pain perception.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.31260 |
| Date | January 2000 |
| Creators | Liao, Chuanhong, 1964- |
| Contributors | Worsley, Keith J. (advisor), Chaubey, Y. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Mathematics and Statistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001810509, proquestno: MQ70456, Theses scanned by UMI/ProQuest. |
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