The technique of functional magnetic resonance imaging (fMRI) is rapidly developing from one of technical interest to wide clinical application. fMRI exploits the fact that brain neural activity produces a change in blood oxygenation level dependent (BOLD) response which is recorded at each point in the brain. In a typical experiment, a subject is given a stimulus or cognitive task, and the statistical question is to relate it to the BOLD response, usually via a linear model. The BOLD response is not instantaneous; it is delayed and smoothed by about 6 seconds. In this thesis we propose a rapid method of estimating and making inference about this delay. Our method is compared to other alternatives, and validated on an fMRI data set from an experiment in pain perception.
Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.31260 |
Date | January 2000 |
Creators | Liao, Chuanhong, 1964- |
Contributors | Worsley, Keith J. (advisor), Chaubey, Y. (advisor) |
Publisher | McGill University |
Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
Language | English |
Detected Language | English |
Type | Electronic Thesis or Dissertation |
Format | application/pdf |
Coverage | Master of Science (Department of Mathematics and Statistics.) |
Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
Relation | alephsysno: 001810509, proquestno: MQ70456, Theses scanned by UMI/ProQuest. |
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