Purpose. To evaluate the role of endovaginal sonography (EVS) and Doppler ultrasound in detecting endometrial carcinoma in women presenting with postmenopausal bleeding. / Materials & methods. We prospectively evaluated 421 women with EVS over a 5-year period. Of these 31 (7.4%) were diagnosed with endometrial carcinoma at histopathology. For each patient, biometric and morphologic parameters, as well as Doppler indices of the endometrium were obtained. / Results. Applying a combination of biometric and morphologic criteria, EVS diagnosed malignancy with a sensitivity of 77% (95% CI: 59%--90%) and a specificity of 84% (80%--87%). Using only biometric criteria (endometrial thickness >2mm indicating malignancy), EVS achieved a sensitivity of 100% (91%--100%) and a specificity of 24% (20%--29%), whereas the corresponding sensitivity and specificity for endometrial thickness >5mm was 74% (55%--88%) and 59% (54%--64%), respectively. The most predictive Doppler index was peak venous velocity (95% CI for odds ratio: 1.08--1.40). / Conclusion. Using a combination of biometric and morphologic sonographic criteria achieves the best accuracy in diagnosing patients with endometrial carcinoma, however at the cost of a decreased sensitivity.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.30731 |
| Date | January 1999 |
| Creators | Reinhold, Caroline. |
| Contributors | Joseph, Lawrence (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Epidemiology and Biostatistics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001754439, proquestno: MQ64436, Theses scanned by UMI/ProQuest. |
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