A physiologically-based multi-compartment model has been developed which makes a priori predictions of the chylomicron cholesterol distribution in the body of a rat. The model considers each organ to be a separate compartment which interacts with all the other organs/compartments through the blood stream. A particle approach has been used since chylomicron cholesterol distribution is regulated more by the particle concentrations than cholesterol concentrations. The chylomicron cholesterol distribution is coupled to the triglyceride contents of the particle. Unsteady nonlinear differential equations have been developed by making mass balances over all the compartments, and the numerical solution of these dynamic model equations is outlined. Finally, this multi-compartment model was used to predict the distribution of chylomicron cholesterol after a bolus injection of chylomicrons or their continuous infusion into the blood. The model results were then compared with the existing literature data points for such systems.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/277981 |
| Date | January 1991 |
| Creators | Siddiq, Ajmal, 1963- |
| Contributors | Fleischman, Gregory J. |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Thesis-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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