Quantification of physiological functions with positron emission tomography requires knowledge of the arterial radioactivity concentration. Automated blood sampling systems increase the accuracy of this measurement, particularly for short-lived tracers such as oxygen-15, by reducing the sampling interval to a fraction of a second. They, however, require correction for tracer delay between the arterial puncture site and the external radiation detector (external delay), and for the tracer bolus distortion in the sampling catheter (external dispersion). / We have evaluated and implemented the "Scanditronix" automated blood sampling system and measured its external delay and dispersion. PET studies of cerebral blood flow and oxygen metabolism using simultaneous manual and automated blood sampling were analyzed and compared. We show that the results obtained with automated blood sampling are more reliable than those based on manual sampling. We also present suggestions to further improve the reliability of quantitative PET studies based on automated blood sampling.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.57009 |
| Date | January 1993 |
| Creators | Vafaee, Manouchehr S. |
| Contributors | Meyer, E. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Medical Radiation Physics.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001327688, proquestno: AAIMM87760, Theses scanned by UMI/ProQuest. |
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