Transmyocardial Revascularization (TMR), a procedure for enhancing myocardial perfusion, is used to treat patients with refractory angina. The mechanism remains elusive. We tested the hypotheses that (a) needle TMR induces nitric oxide synthase (NOS) enzyme, which is potentially capable of causing vasodilatation to augment blood flow; (b) that needle TMR can recruit smooth muscle cells for vessel development (arteriogenesis) in the late phase of TMR; and (c) that needle TMR improves myocardial regional blood flow in the early and late phases of TMR under either rest or stress conditions. We conclude that, both experimentally and clinically, the validity of TMR as an effective therapy for myocardial ischemia remains questionable and that the placebo effect in TMR treatment cannot be excluded.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.80325 |
| Date | January 2004 |
| Creators | Luo, Chwan-Yau, 1960- |
| Contributors | Chiu, Ray C-J (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002032006, proquestno: AAIMQ98694, Theses scanned by UMI/ProQuest. |
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