There is tremendous enthusiasm for the utilization of angiogenesis as a therapeutic modality for atherosclerotic arterial disease. Augmentation of physiological neo-vascularization in cardiovascular disease can be achieved through different pathways. Marrow stromal cells may serve as an ideal cellular vehicle for the in vivo delivery of therapeutic proteins or production of these proteins by the cells themselves. The use of autologous marrow stromal cells is highly desirable since marrow stromal cells are abundant and available in all human of all ages and they are easy to harvest and reimplant without the fear of rejection. Our primary data showed that marrow stromal cells injected locally into ischemic animals promote angiogenesis. Exploring various routes of delivery is important for developing these cells as a novel therapeutic tool for treatment. We found that injecting these cells intravenously in high doses has a beneficial effect in restoring blood flow into the ischemic area in the ischemic hind limb animal model. Implantation of these cells into distant organs did not show any local or remote effects.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.97891 |
| Date | January 2005 |
| Creators | Alsabti, Hilal. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | © Hilal Alsabti, 2005 |
| Relation | alephsysno: 002326786, proquestno: AAIMR24600, Theses scanned by UMI/ProQuest. |
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