A prospective, randomized, experimental study was performed to assess the treatment of mandibular continuity defects by distraction osteogenesis, using the rabbit model. This method of treatment was compared to a control group, which had treatment by traditional means, using a fixation plate. Eight animals were randomized into one of the two groups. / The treatment methods were assessed by clinical, radiographic, and histologic examinations. / Clinically, the experimental specimens had greater dimensions of bone formation in the defects than their matched controls. / Radiographically, there was a higher percentage of radiopacity in the defects of the experimental group compared to the controls, although not statistically significant. / Histologically, there was a statistically significant higher percentage of bone fill in the defects of the experimental group compared to the controls. Three of the four experimental specimens (75%) developed bony union at the 'docking site'. / A cost-efficient animal model was developed for the study of bifocal distraction in the treatment of mandibular continuity defects. The critical-sized mandibular defect in the rabbit model was found to be a minimum of 4mm.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.27324 |
| Date | January 1996 |
| Creators | Gervais, Normand Laurier. |
| Contributors | Clokie, Cameron (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Faculty of Dentistry) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001565268, proquestno: MQ29699, Theses scanned by UMI/ProQuest. |
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