A new transform analysis method is described for the quantitative analysis of radioactive inert gas washout curves to measure regional cerebral blood flow (rCBF) by the intra-arterial bolus injection technique. This method is based upon a transformation of the original data, recorded with a unique semiconductor miniature detector system. It combines the valid features of the two most frequently used analysis techniques, namely, the compartmental and the stochastic, or height-over-area (H/A) methods. At the same time, the method avoids the recognized limitations or deficiencies of these two approaches. It gives for the first time information about the 'spectral' distribution of blood flow in various vascular compartments. The transform method, together with the combined use of beta-emitting krypton-85 and gamma-emitting xenon-133, has thus made possible a more exact interpretation of dynamic changes in rCBF as illustrated by its application in a variety of experimental and clinical models of disordered cerebral circulation.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.68573 |
| Date | January 1980 |
| Creators | Meyer, Ernst. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Neurology and Neurosurgery) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000092296, proquestno: AAINK52036, Theses scanned by UMI/ProQuest. |
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