Ventilation by high-frequency body-surface oscillation (HFBSO) was studied in normal rabbits. Adequate ventilation and acceptable gas exchange took place during HFBSO from 3 to 15 Hz. The tidal volume required to maintain a normocapnic state was established at each frequency studied. Using catheter-tip micromanometers inserted in the esophagus or the superior vena cava, new techniques to measure high-frequency intrathoracic pressure oscillations were developed. Using a gamma-function to fit the thermodilution curve, a new technique was developed to measure the cardiac output in small animals. No detrimental hemodynamic effect was found during HFBSO used either for normocapnic ventilation or with large pressure oscillations (30 cm H$ sb{ rm 2}$O) in the body chamber. Finally, during normocapnic ventilation by HFBSO in normal rabbits, the mechanical behavior of the respiratory system was characterized using transfer impedances.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.75917 |
| Date | January 1989 |
| Creators | Chartrand, Daniel, 1955- |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Division of Experimental Medicine.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000911101, proquestno: AAINL52302, Theses scanned by UMI/ProQuest. |
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