Objectives. (1) To Determine the presence of HPV 6, 11, 16, 18, 31, 33, 35, 52b, 58 subtypes in resected oral/oropharyngeal SCCA cancer and associated lymph nodes. (2) To Determine if a relationship exists between koilocytosis, tumor grade, stage, or prognosis. / Methods. Retrospective analysis and pathology review of patients with SCCA of the oral cavity at McGill in the last 5 years was performed. Age at diagnosis, risk factors, tumor stage, grade, koilocytosis, treatment, outcome, and presence of HPV by PCR were analysed. / Results. 199 patients included were included in the analyses; 5 years mortality was 18.5%. 146 cases reviewed by pathology revealed 67% koilocytosis. One sample was positive for HPV subtype 35 as determined by PCR. Radiotherapy (p<0,5) and complications from radiotherapy (p<0.5) significantly affected survival. / Conclusions. Many oral SCCA's do not contain HPV 6, 11, 16, 18, 31, 33, 35, 52b, 58 subtypes. Given the high prevelence of koilocytosis, probe for other subtypes should be utilized. Mortality rates and survival are similar to those published in the literature. The presence of koilocytosis, it is not related grade, stage or prognosis. Only radiotherapy and its complications affect survival.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.83960 |
| Date | January 2005 |
| Creators | Al-Qahtani, Khalid Hussain |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Otolaryngology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002261563, proquestno: AAIMR22699, Theses scanned by UMI/ProQuest. |
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