Introduction. Ototoxicity refers to medication-caused auditory and/or vestibular system dysfunction resulting in hearing loss or dysequilibrium. The potential damage that antibiotics eardrops can produce when placed directly into the middle ear in some cases is still unknown. / Objectives. To determine the safety of use of the new ciprofloxacin/dexamethasone otic drops in patients without an intact tympanic membrane. / Materials and methods. Ciprodex/dexamethasone eardrops were tested in an animal and human model. The animal part was performed in 13 adult chinchillas; Auditory Brainstem Response (ABR) was used. For the human part, twenty subjects were enrolled in the study; Distortion Products Otoacoustic Emissions (DPOAE) testing was used. / Results. Animal Part: after the tube insertion ABR threshold mean value was 19.6+/-13.3 dB for all the animals. On the last evaluation (day 60), the mean threshold was 19+/-13 dB for the experimental ears, and 13.7+/-12.2 dB for the control ears, this overall analysis showed no significant effect (p-value = 0.661). Human Part: the mean thresholds for the pre-treatment test were 4.87+/-6,34 dB for the DP value and -0.87+/-7.93 dB for the Ns value. In the post-treatment evaluation the mean thresholds were 3.48+/-4.40 dB for the DP value and -8.02+/-7.57 dB for the Ns value. / Conclusions. The use of CiprodexTM eardrops seems to be safe when instilled in ears without an intact tympanic membrane.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.97975 |
| Date | January 2005 |
| Creators | Munguia, Raymundo. |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Otolaryngology.) |
| Rights | © Raymundo Munguia, 2005 |
| Relation | alephsysno: 002333261, proquestno: AAIMR24749, Theses scanned by UMI/ProQuest. |
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