Standard therapy for abdominal aortic graft infection involving resection of the graft and extranatomic bypass, carries significant morbidity and mortality due to aortic stump rupture and limb loss. This thesis evaluates the feasibility of combining in situ graft replacement with a highly vascular tissue flap as an alternative approach to this problem. / In sixty-nine pigs, a segment of a polytetrafluoroethylene (PTFE) graft was interposed in the infrarenal abdominal aorta. Staphylococcus aureus was then used to infect the graft. One week later the animals were divided into six treatment groups where two different types of pedicled muscle flaps were used to treat the infection. The flaps were designed from the rectus abdominis and the seromuscularis of the jejunum. / The results showed that graft infection could be controlled if either of the muscle flaps were used. Graft thrombosis did not occur if the infected graft was changed with a new PTFE graft. / Vascularized tissue flaps avoid thus potentially fatal aortic stump rupture and may improve limb salvage in this difficult clinical problem.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.59419 |
| Date | January 1989 |
| Creators | Mehran, Reza John |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Division of Surgical Research.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001233174, proquestno: AAIMM63599, Theses scanned by UMI/ProQuest. |
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