This project is concerned with the relationship between type-1 diabetes and auditory pathology. In this dissertation I compared hearing sensitivity, cochlear function, and peripheral auditory neural function (afferent and efferent) in young adults with type-1 diabetes in comparison to matched controls. As a secondary objective I explored the influence of covariates, such as diabetes control, sex, and noise exposure. My findings suggest that the persons with type-1 diabetes demonstrated early signs of cochlear pathology and that this damage was related to sex and history of noise exposure. In addition, I demonstrated the utility of low-level stimulus evoked otoacoustic emissions in showing reduced cochlear function in participants with higher noise exposure and type-1 diabetes despite otherwise normal auditory function outcomes. Identification and recognition of early indices of cochlear pathology may allow intervention and prevention of noise related hearing loss in persons with and without type-1 diabetes.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-09142010-120712 |
| Date | 15 September 2010 |
| Creators | Spankovich, Christopher |
| Contributors | Daniel H Ashmead, Benjamin WY Hornsby, Bill Russell, Linda J Hood |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-09142010-120712/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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