Milk protein has been implicated as a factor in the development of atherosclerosis. Significantly higher titers of antibodies (P < 0.0002) toward milk antigens were observed in patients suffering from coronary heart disease as compared to age matched controls. These hemagglutination titers were not sex related but may have been related to age. Specificity of the antigen-antibody reaction was demonstrated by a hemagglutination inhibition test. The complement fixation test was evaluated and was less sensitive than the tanned hemaggIutination test. Treatment with 2-mercapto-ethanol resulted in reduced hemagglutination titers, indicating that significant antibody activity may be due to IgM. A special application of the Combs test detected specific antibodies on the surface of tanned and coated RBC which did not otherwise produce detectable agglutination.
| Identifer | oai:union.ndltd.org:ucf.edu/oai:stars.library.ucf.edu:rtd-1379 |
| Date | 01 January 1977 |
| Creators | Spinos, Efstathios |
| Publisher | Florida Technological University |
| Source Sets | University of Central Florida |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Retrospective Theses and Dissertations |
| Rights | Written permission granted by copyright holder to the University of Central Florida Libraries to digitize and distribute for nonprofit, educational purposes. |
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