Indiana University-Purdue University Indianapolis (IUPUI) / Autonomic control of the heart results in variations in the intervals between heart
beats, known as heart rate variability. One of the defining components of autonomic
control is the baroreflex, a negative feedback controller that balances heart rate and
blood pressure. The baroreflex is under constant command from the branches of the
autonomic nervous system. To better understand how the autonomic nervous system
commands the baroreflex, a baroreflex reflexogenic animal protocol was carried out.
Heart rate variability analysis and baroreflex sensitivity were used to quantify the
neural control of the heart. This thesis reconfirmed the existence of sexually dimorphic properties in the baroreflex through the use of heart rate variability analysis
and baroreflex sensitivity. It was discovered that there are many caveats to utilizing
heart rate variability analysis, which have to be addressed both in the experimental
protocol and the signal processing technique. Furthermore, it was suggested that the
slope method for quantifying baroreflex sensitivity also has many caveats, and that
other baroreflex sensitivity methods are likely more optimal for quantifying sustained
activation of the baroreflex. By utilizing various heart rate variability signal processing algorithms to assess autonomic tone in Sprague-Dawley rats during rest and
sustained electrical activation of the baroreflex, the null hypothesis was rejected.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/22697 |
| Date | 05 1900 |
| Creators | Bustamante, David J. |
| Contributors | Schild, John, Yoshida, Ken, Salama, Paul |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Thesis |
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