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Previous issue date: 2009-10-20 / Hemoglobinopathies are the most common inherited disorders in humans; the
most frequent are hemoglobins S and C. This study evaluates the prevalence of
hemoglobin patterns at the city of Goiânia, state of Goiás, Brazil, using neonatal
screennig. Prevalence was compared between exams from the public and
private systems. Blood samples from 90,127 newborns were obtained.
Hemoglobinopathies were identified in a total of 61 (7:10.000) newborns. The
prevalence in public and private systems was 7 and 3 per 10,000 respectively
(p=0.081). In 3,243 (371:10,000) hemoglobinopathy traits were detected. The
public system´s prevalence was 400:10,000 and in the private system it was
177:10,000 (p=0.0001). The prevalence of sickle cell disease was 4.3:10,000
live birth overall; in the public system, it was 5:10,000 and in the private system
it was 2:10,000 (p=0.133). We can conclude that sickle disease is of high
prevalence in children at public and private systems. The neonatal screening
information is of paramount importance for early diagnosis of sickle disease and
people with sickle traits / As hemoglobinopatias são as desordens hereditárias mais comuns nos seres
humanos, sendo as mais freqüentes as hemoglobinas S e C. O presente estudo
avaliou a prevalência de hemoglobinopatias no Município de Goiânia através da
análise da triagem neonatal, e comparou as prevalências de hemoglobinopatias
entre a rede pública e privada. Amostras de sangue de 92.127 recém-nascidos
foram analisadas. Um total de 61 recém-nascidos apresentaram
hemoglobinopatia (7:10.000). Na rede pública e privada a prevalência foi de 7 e
3 por 10.000, respectivamente (p=0,081). Traço de hemoglobinopatia foi
observado em 3.423 amostras (371:10.000); a rede pública com prevalência de
400:10.000 e a privada com 177:10.000 (p=0,0001). A doença falciforme teve
prevalência de 4:10.000 nascimentos, sendo 5:10.000 na rede pública com e
2:10.000 na privada (p=0,133). Conclui-se que a doença falciforme apresenta
alta prevalência e acomete crianças usuárias das redes pública e privada de
saúde. A triagem neonatal é de extrema importância para a detecção precoce
de pacientes com doença falciforme e de portadores assintomáticos
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.bc.ufg.br:tde/1765 |
| Date | 20 October 2009 |
| Creators | RUIZ JÚNIOR, Everaldo |
| Contributors | COSTA, Paulo Sérgio Sucasas da, ANDRADE, Ana Lúcia Sampaio Sgambatti de |
| Publisher | Universidade Federal de Goiás, Mestrado em Ciências da Saúde, UFG, BR, Ciências da Saúde - Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFG, instname:Universidade Federal de Goiás, instacron:UFG |
| Rights | info:eu-repo/semantics/openAccess |
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